(full paper is archived in the Miller Library)
Title: The role of serotonin in early development of the sea urchin Strongylocentrotus purpuratus
Student Author(s): Weaver, Alissa
Location: Final Papers Biology 175H
Date: June 1990
Abstract: Six serotonin antagonists, cinanserin, methiothepin, spiperone, metergoline, ketanserin, and methysergide were all found to delay the first two divisions of sea urchin embryos. Three serotonergic agonists, DOI, RU24969, and phenyl biguanide were also found to delay cleavage, although more weakly than the antagonists. Cleavage delays caused by 10 uM metergoline and 10 uM ketanserin were reversed by serotonin. Serotonin alone was found to speed up cell division over controls. Cytological studies showed the serotonin antagonists metergoline, ketanserin and methysergide delayed karyokinesis as well as cytokinesis.