Series I consists of correspondence both of a personal nature and of a business nature. The extent of the family correspondence is fairly significant. Fanny Howe kept much of the correspondence sent among family members, in particular between her father, Mark DeWolf Howe, and mother, Mary Manning, during the years 1935 to 1945. Also of note is the set of correspondence between Helen Howe (Mark DeWolf Howe's sister) and Fanny Quincy Howe (Mark DeWolf Howe's mother). This is important primarily because Fanny Howe, as a student in the writing program at MIT, submitted a proposal to write a biography of Mark DeWolf Howe and Helen Howe entitled Predictable Destitinies. Also of interest is Mark DeWolf's correspondence to Fanny Howe, 1957 - 1959, because much of the material contained in these letters would be used in one of Fanny Howe's writings entitled Ofay. Included in the general correspondence are Nelson Aldrich, Ed Asner, Russell Banks, Samuel Beckett, Robert Creeley, Robert Lowell, Norman Mailer, Bernadette Mayer, and May Sarton.

Series II is a collection of material that relates to Fanny Howe's family and personal history. Included in this series are such items as Fanny's primary school results, her "autobiography" relating all the influences that affected her growth as a writer, an autobiography by Helen Huntington Howe entitled A Poor Innocent Young, and some photographs of Fanny. [Of note is material in Series I, box 3, folders 6 - 8 which corresponds to family history but, because of the order of material, could not be placed in Series II]

Series III, contains Fanny Howe's poetry, most of which has no collective title but is used for publications such as "Alsace-Lorraine," "Written in Eire," and "Eggs."

Series IV consists of Fanny Howe's literary manuscripts. These include Body and Soul, Bronte Wilde, Famous Questions, Reconstruction, Saving History, Un-American Activities, and material relating to The White Slave. [A text copy of Ofay is placed in Series VI because of the large size of the text]

Series V contains school term papers, short stories, articles, and book reviews.

Series VI contains miscellaneous material such as book reviews, plot summaries, and artwork for Howe's publications, along with publications by colleagues of Fanny Howe. Of mention in this series is "A Bernadette Mayer Reader" which contains the poetry of Bernadette Mayer. Also included is a copy of the text Ofay and the layout design for Robeson Street.

Series VII consists of the notebooks and journals kept by Fanny Howe. The majority of these notebooks contain personal entries, poetry, short stories, and outlines, including original manuscripts for the publications Bronte Wilde and Saving History. One notebook contains the original format to the work Reconstruction.