%eadnotat; ]> PUBLIC "-//Stanford University::Libraries::Dept. of Special Collections::Stanford University Archives//TEXT (US::CSt::SC 358::Paul Berg Papers)//EN" "sc0358"Guide to the Paul Berg Papers, 1953-1986Processed by Special Collections staff; machine-readable finding aid created by Patricia White© 1998

The Board of Trustees of Stanford University. All rights reserved.

Machine-readable finding aid derived from MS Word. Date of source: 1989.Finding aid is written in English.Guide to the Paul Berg Papers, 1953-1986Collection number: SC 358Department of Special Collections and University Archives Stanford University Libraries Stanford, CaliforniaSpecial Collections staff1989Patricia White

© 1998 The Board of Trustees of Stanford University. All rights reserved.

Descriptive SummaryPaul Berg Papers, 1953-1986Stanford University Archives SC 358Berg, Paul, 1926-41 linear feetStanford University. Libraries. Dept. of Special Collections and University Archives.Administrative InformationAccess Restrictions

Search files, personnel files, letters of recommendation, and other confidential materials are restricted.

Publication Rights

Property rights reside with the repository. Literary rights reside with the creators of the documents or their heirs. To obtain permission to publish or reproduce, please contact the Public Services Librarian of the Dept. of Special Collections and University Archives.

Provenance

Gift of Paul Berg, 1989 and 1991

Preferred Citation:

[Identification of item], Paul Berg Papers, SC 358, Stanford University Archives, Stanford, Calif.

Biography

Biochemistry Professor at Stanford University since 1960, Berg received the Nobel Prize for chemistry in 1980 for "fundamental studies of the biochemistry of nucleic acids with particular regard to recombinant DNA." He was appointed Director of Stanford's Center for Molecular and Genetic Medicine in 1984. In 1967, Berg, working at the Salk Institute, redirected his study of protein synthesis from bacterial cells to tumor viruses. By 1970, this research had led Berg and his associates to conclude their experiments could form the basis of "man-made living matter." Spurred by growing ethical questions, Berg chaired the National Academy of Sciences 1975 conference which focused on the potential hazards of recombinant DNA research and resulted in the policy and quidelines which form the framework for genetic research.

Biography1952-1954:American Cancer Society fellow, Institute in Copenhagen and Washington University School of medicine. His work was concerned with clarifying how the master substances of heredity, DNA, transfers its genetic information to analogous molecules, known as RNA, which serve as templates for making proteins.1954:Scholar in cancer research at University of Washington. His work on the genetic apparatus that directs the synthesis of protein earned Berg the Eli Lilly award in biochemistry in 1959.1960:Stanford School of Medicine, associate professor of biochemistry and until 1967 continued work on protein synthesis. All this work was based on bacterial cells, but in 1967, he decided to do research on animal cells, taking a year's leave. He worked at the Salk Institute on tumor viruses.1970:By about 1970, Berg and his associates began to think how they might use tumor viruses to bring new genes to animal cells - "man-made living matter" or "engineered a new genetic molecule." This raised the question of ethics, so, in 1973, they stopped experimentation.1975:National Academy of Sciences sponsors meeting, chaired by Berg, whose purpose is to conduct a survey of potential hazards involved (Asilomar). This resulted in a set of recommendations to establish guidelines to put certain constraints on experiments; these were organized by the NIH and are used as guidelines today.1980:Berg was awarded the Nobel Prize in chemistry for "fundamental studies of the biochemistry of nucleic acids with particular regard to recombinant DNA." Berg was also responsible for shaping "policy" for dealing with possible risks of recombinant DNA research.1984:Appointed director of Stanford University's Center for Molecular and Genetic Medicine.Scope and Content

Collection focuses on Berg's work with recombinant DNA and includes professional correspondence, 1959-1985; research lab notebooks for the years 1953-1986 which document his work with protein synthesis in bacterial cells and tumor viruses; records concerning the National Academy of Sciences conference on recombinant DNA research guidelines; records from his Stanford positions including administrative files, grant files, departmental records, student files, lectures, and symposia; reprints and illustrations; and videotapes and audiotapes.

Container ListSeries 1 Correspondence, 1959-198511Correspondence A - J 1959 - 196212Correspondence K - Z 1959 - 196213Correspondence 1962 - 196414Correspondence A - B 1965 - 196615Correspondence C - D 1965 - 196616Correspondence E - G 1965 - 196617Correspondence H - K 1965 - 196618Correspondence L - N 1965 - 196619Correspondence O - R 1965 - 1966110Correspondence S 1965 - 1966111Correspondence T - Z 1965 - 1966112Correspondence on Positions 1959 - 1967113Comm. on Medical Education - Drafts and reports114NAS - letters of congratulations, 1966115Gordan Conference (Nucleic Acids), 1966116NIH Study Section - Physiological Chemistry, corresp. 1964 - 1965117NIH Study Section, correspondence 1964 - 1965118Comm. on Public Exercises & Public Events 1968 - 1969119University Public Health Committee corresp., 1968 - 1969120Comm. on Committees (Proposed Research) corresp., 1968 - 1969121NAS - National Research Council, correspondence, 1966122NAS - Life Sciences panel, correspondence, 1966123NAS, correspondence, 196621Journal of Biological Chemistry, Publications Committee, correspondence, 1965 - 196722Journal of Molecular Biology, correspondence, 1967 - 197023Orbit correspondence, 196924NAS, correspondence, 1967 - 196825Post-doctoral applications, rejected 196926Correspondence A - H 196927Correspondence I - O 196928Correspondence P - Z 196929Correspondence A - H 1970210Correspondence I - O 1970211Correspondence P -Z 197031Correspondence, Chron file, 197032Correspondence, Chron file, January - June 197133Correspondence, Chron file, July -November 197134Correspondence A - L 197235Correspondence M - Z 197236Correspondence, Chron file, 197337Correspondence A - K 197338Correspondence M - Z 197339Correspondence, Faculty/Technical Positions, 1973310Correspondence post-doc rejects, 1973311Correspondence, Chron file, 1974311Correspondence A - N 197441Correspondence N - Z 197442Correspondence, Faculty positions, 197443Correspondence A - Z 197544Correspondence, post-doc rejects, 197445Correspondence NSF Human Cell Program 1971 - 197446Correspondence NSF Human Biology Steering Comm. 1970 - 197647Correspondence "President's Biomedical Research Panel - Palade's Cluster" 197548Correspondence Jane Coffin Childs Fund, 197249Correspondence, University Comm. on Research Policy 1972 -1976410Correspondence with Rich [Med. School Dean] 1973411Correspondence Jane Coffin Childs April 1973412Correspondence Jane Coffin Childs meeting, 1974 Oct. 4413Correspondence Jane C. Childs Spring Meeting 1975414Correspondence, Council on Analysis and Projection415Correspondence, Council on Analysis and Projection416Scientific American417National Medal of Science, nomination A. Kornberg, 196951Correspondence A - C 1976 - 197852Correspondence D - G 1976 - 197853Correspondence H - L 1976 - 197854Correspondence M - Q 1976 - 197855Correspondence R - T 1976 - 197856Correspondence U - W 1976 - 197857Correspondence A - C 1978 - 197958Correspondence D - F 1978 - 197959Correspondence G - I 1978 - 1979510Correspondence J - N 1978 - 1979511Correspondence R 1978 - 1979512Correspondence S - Z 1978 - 1979513Letters of Recommendation, A - D 1973 - 1976514Letters of Recommendation, E - H 1973 - 1976515Letters of Recommendation, J - O 1976 - 1977516Letters of Recommendation, R - Z 1972 - 1978517Post-doc application rejects, Jan - June 1979518Post-doc application rejects, July - December 197961-79Travel Correspondence - lectures/symposia 1982 - 19857Travel Correspondence - lectures/symposia 1980 - 1981Series 2 Research lab notebooks, 1953-1986Paul Berg:81Methods (Salk Institute) 1967/6882Mut 51 - 78 (Salk Institute) 196783RNA - Isolation from Tissue Cultures 196784PY (P.B.) (La Jolla) 196785Mut 79 - 141 (Salk Institute) 196886Mut 142 - 225 (Salk Institute) 1968/6987AA - Incorporation (Amino acids ?) 196888EM (Electron Microscopy) of TSA viral DNA's 196889Nicking-Enzyme (F.C.) 1969810Nicking-Enzyme II (F.C.) 1969811Virus I V-1 to V-57 (M.D.) 1969/71812DNA-Synthesis in Nuclei (M. D.) 1970813c-RNA-Synthesis in vitro (Py) 1970/71814Cot 1 1970/71815Hin Fragments (SV 40) 1972816Cot 2 1972111Acetate III, 1954-55112Acetate IV, Part 1, 1955-56113Acetate IV, part 2, 1955-56114Synthesis of amino acyl adenylates, 1956115Synthesis and study of adenyl-amino acids 1956 Sept. - 1957 May116Amino acid incorporatio into RNA, I, 1957 May - 1958 July117Amino acid incorporatio into RNA, II, 1958 July - 1959 April118Purification of e. coli RNase 1958-59119Purification of RNA, 1959 Jan. - May1110Acetate incorporation 1964 Mar. 18 - 1964 June 21111Acetate incorporation 1964 June 23- Sept. 221112Purification of amino acid activating enzymes 1958 June - October1113Methionyl Act-Enz (Yeast) I, 1955-561114Unlabeled [Acetate II ?], 19541115Acetate I, 1953-54121GLy-RNA Synthetase I, 1965 July 11 - 1966 Aug. 26122GLy-RNA Synthetase II, 1966 Aug. 25 -1967 Apr. 12123GLy-RNA Synthetase III, 1967 July 14 - Aug. 14124Prep. & triphosphates125Growth curves 1966 Sept. 19 - 1967 July 6131Preparation of ARPP+P+, 1964132Vancouver 1956133Paris experiments, 1961134Polyama Cot Data135Science article, 1968136General thoughts on suppression137Notes for paper on level of suppression138Mechanism of missense suppressionDieckmann/Berg:91COT II A 197292COTs for publication93SV Plaque Morphology Mutants 197394Isolation of SV 40 Complex 197395SV 40 Mutants (Plaque Assays) 1974/197596SV 40 Mu, Dn'ase (Mutants M. D.) 1975/197697SV 40 Mu Late and Early (dl 861) 1975/197698SV 40 Mu, Complementation (Mutant Characterization Complementation) 197699Replication Ori 1976910SV 40 Mu, Hpall, Early and Late 1976911Lagerkrist 1977912Plasminogen Activator 1977/1978913Tag Function (Doefler), Dieckmann 1978914Restriction Mapping of Yeast t-RNA Inserts 1978915beta Globin, 2kb in SV 1979916alpha- and beta-Globin in SV 1979Berg/Dieckmann/Hoshi:101Mouse Embryos 1980102NIH Guidelines 1980, 1982, 1986103TC June Hoshi 1970104[Untitled] 1974/75105[Untitled] 1976/77106[Untitled] 1978 to 1980107[Untitled] 1980/81108[Untitled] 1982 to 1986109Plaque Assays 1972 to 1979Notebooks by others:139Peter Powell's paper and notes126Jack Preiss: ACC - adding enzyme, Book 1, 1959-60127Jack Preiss: ACC - adding enzyme, Book 2, 1959-60128Jack Preiss: ACC - adding enzyme, Book 3, 1959-60129Jack Preiss: ACC-RNA end group identification1210Jack Preiss: E. Coli Lysates, 1958 Sept. - 1959 May1211Fred Bergmann notebooksSeries 3 Recombinant DNA, 1973-1977History 1973 - 19771310Correspondence, A - H (pre Asilomar), 1974 - 19751311Correspondence, I - R (pre Asilomar), 1974 - 19751312Correspondence, S - Z (pre Asilomar), 1974 - 19751313Asilomar Administrative Materials (conference coordinator)1314Asilomar Meeting Material1315Final Report (originals)1316Asilomar statement documents1317NAS Final Report (Working Papers)1318Correspondence (post Asilomar) 1975141Correspondence (post Asilomar) 1976 - 1977142Correspondence (pre Asilomar)Papers 1973 - 1977143News articles prior to 1974144News articles 1974145News articles 1975146News articles 1977147Recombinant DNA Controversy at Ann Arbor, Michigan148NIH Director's Advisory Committee Meeting, Feb. 9 -10, 1976149Kennedy Hearings Cambridge Controversy1410Non-NIH Guidelines (USA & abroad)151Index, RDR Reference lists, RDR Master of selected articles152Correspondence (MIT meeting) 1974153Manuscripts 1974 - 1977154Recombinant DNA Research Vol. 1, August 1976:US Dept HEW, NIH155Draft: Environmental Impact Statement Guidelines for research involving Recombinant DNA Molecules 1976 Aug. 19156NIH Recombinant DNA research minutes/meeting reports etc., 1976 - 1977157Cambridge City Council Matters158Published Reactions to NIH Guidelines on RD Research159Reply to Chargaff letter1510WHO on Recombinant DNA Molecules1511Germ warfare correspondence1512"Genetic Scientists: Facing the Mutant Microbe," Rolling Stone, June 19, 19751513"Genetisk Manipulation," INGENIOREN, Sept. 22, 197722DNA: meetings/hearings/publications23DNA: essays25Recombinant DNA articles/clippings, 1976 - 197725DNA: copies of Berg's Senate TestimonySeries 4 The Salk Institute 1972 - 19761514CV of Personnel for Dr. Paul Berg1515Salk Institute: Correspondence, Holley's Lab, Salk Personnel listing1516Banbury Center - Cold Spring Harbor Lab, ca. 1977(Initial attempts at Berg et al II - corresp -, Bio-hazards of Viruses)Series 5 Administrative files, 1968-1984680Manuscript - Biofuture: Confronting the Genetic Era,pp. 1 - 465, by Burke K. Zimmerman, n.d.16Grant files ca. 1974 - 198216-17Reprints171Faculty applications, post-doc applications172Staff Meeting Minutes 1969 July 1173Faculty Meetings - Agendas - Minutes, 1968 - 1969174Faculty Senate - Agenda - Minutes, Jan - Dec 1971175Faculty Meeting, 1971 - 1972176Faculty Meeting, 1972 - 1973181Faculty Minutes and Memos 1979 Sept. - 1980 Aug.182Faculty Minutes and Memos 1979 Sept. - 1980 Aug.183Faculty Minutes and Memos 1980 Sept. - 1982 Aug.184Executive Committee Dec 1971 - March 1973191Executive Committee April - Dec 1973192Weekly-Minder 1971 - 1972193Weekly-Minder 1972 - 1973194Hearings/Committees on Recombinant DNA (US Senate/State legislatures) 1976 - 197720Misc. Grant files and Disk files20-21Post doc files 1981-198421Trip Files: lectures/symposia, 1975 - 198022Trip files/lectures/symposia23National Academy of Sciences Council Meeting 1980 Oct. 26241National Academy of Sciences242Congressional Hearing 1981 May 6243Manuscript Reviews completed244Potential post-doctoral fellows245Seminar Invitations declined246Misc. check requests247Medical School Biohazards CommitteeSeries 6 Audio Visual Materials26-27Illustrations for publications28Dr. Berg Seminar, Part I and Part II, 1987 Nov. 112 VHS tapes28Berg "Genetic Engineering: Challenge and Responsibility," 1975 Mar. 73/4 inch video tape (1)28Dr. Berg, "Dissections and Reconstruction of the SV40 Genome," NIH Lecture 1976 Nov. 171 audio tape (reel to reel)28William H. Stein, lecture at Rockefeller University, 1984 Mar. 161 audio cassette28Untitled1 audio cassetteSeries 7 Additional Papers (ACCN 1991-020)11News clippings on DNA research, 1975 - 197612Business correspondence, 1975 - 197613Personal correspondence, re: Asilomar, 1975 - 197614Comments and revisions of Asilomar Report: drafts and letter, 197515News clippings on Ethics and Guidelines for Genetic Research, 1975 - 197616Essays on the ethics of science/DNA research:The Benefits of Saying YES! by Paul Ehrlich (1975)Toward an International Ethic of Science by Sergent Shriver (1975)Untitled - final version of the bioethics story with letter to Berg from S. F. Moran (1975)Scientists with a Secret" by Spencer R. Weart (1976)17Memos and info on conferences: Asilomar Conference - programs, roster, memo; Joint MRC/ARC/SRC Conference on Recombinant DNA, (1975)18International Conference on Recombinant DNA Molecules: memos, contract and budget19ASILOMAR Conference: "Summary Statement of the Asilomar Conference on Recombinant DNA Molecules" manuscript and "Report of the Organizing Committee of the Asilomar. . ." drafts110DNA Testimony to Senate Committee, 1977:incoming and outgoing correspondence, testimony by Berg for the Subcommittee on Science, Technology, and Space111Recombinant DNA Correspondence, 1979 - 1991112Addresses/Conferees113Recombinant DNA: correspondence and related matters, 1976 - 1980114Notebook: misc. letters and reports on recombinant DNA and conferences, NIH Advisory Committee, Environmental Impact Statement21Notebook, 1975:Current Guidelines for Research in Recombinant DNA molecules, Members of the Recombinant DNA Program Advisory Committee - memos, letters, drafts, minutes